Development of solid-state water dispersible granule formulation from eucalyptus leaf extracts and bioefficacy assessment against mosquito larvae

Water-dispersible granule (WDG) formulation made from extracts of Eucalyptus globulus may be a potential green larvicide based on sustainable chemistry to lessen the usage of harmful chemicals in mosquito control. Through a pseudo-ternary diagram, compatible wetting agent sodium dioctyl sulfosuccinate (SDS) and dispersing agent potassium polycarboxylate (PP) were identified suitable for solid state engineered WDG formulations. FESEM has verified microcrystalline cellulose (MCC) as a pore former and disintegration accelerator in dry flowables. The granule dispersion had residual efficacy against 3rd-instar larvae of Aedes aegypti, with a 100% mortality rate, and ovicidal effects on recently placed eggs, where no hatching was seen. When dry flowable suspension’s ability to inhibit oviposition was evaluated, it was shown that gravid females laid 85% fewer eggs. LC–ESI–MS analysis identified macromolecular bioactive phenolic acids mainly gallic acid, quinic acid and flavonoids such as quercetrin. The FTIR and 13 C NMR investigation revealed that all adjuvants are compatible with eucalyptus extracts. This finding indicates that waste E. globulus leaf has potential for user and environment-friendly mosquito control and waste utilization.