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This research aims to evaluate the protective effects of vitamin D and curcumin on knee osteoarthritis progression in a rat model.

July 15, 2026NutrientsOpen Access

Vitamin D and Curcumin Mitigate ACLT + MMx-Induced Knee Osteoarthritis by Improving Antioxidant-Related Nrf2/HO-1 Expression and Reducing Synovial Inflammation

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Randomized trial evaluates vitamin D and curcumin's effects on knee osteoarthritis, suggesting potential protective benefits.

This research aims to evaluate the protective effects of vitamin D and curcumin on knee osteoarthritis progression in a rat model.
Osteoarthritis was induced in rats via ACLT + MMx surgery.
Six groups were used: Sham, OA-control, vitamin D, curcumin, and Vitamin D + Curcumin (n = 6/group).
Functional outcomes and body weight were monitored for 12 weeks with histological assessment of cartilage damage.
OA-control rats exhibited significant knee swelling and impaired weight-bearing abilities.
Vitamin D and curcumin treatments improved functional measures and preserved cartilage integrity better, especially with the combination treatment.
Increased levels of Nrf2/HO-1 mRNA and less inflammatory cytokines were observed with treatments.

Mende et al. (2026) studied this question.

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