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July 15, 2026AnimalsOpen Access

Integrated ATAC-Seq and RNA-Seq Reveal Candidate Regulatory Genes and Chromatin Accessibility Associated with Intramuscular Fat Deposition: An Animal Trial in Hezuo Pigs

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Authors

JYJie YangXHXiaoyu HuangQYQiaoli Yang

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Overview

Randomized trial reveals regulatory genes involved in intramuscular fat deposition in Hezuo pigs, suggesting pathways for meat quality improvement.

Key Points

  • This study aims to uncover genes and mechanisms that regulate intramuscular fat accumulation in Hezuo pigs.
  • Longissimus dorsi muscle samples from Hezuo pigs with extreme intramuscular fat contents were analyzed.
  • Chromatin accessibility profiling and transcriptome sequencing were performed on these samples.
  • Comparative analyses identified differentially accessible chromatin regions and differentially expressed genes.
  • Identified 2201 differentially accessible chromatin regions and 588 differentially expressed genes between high and low intramuscular fat groups.
  • Functional enrichment showed involvement in lipid metabolism and signaling pathways.
  • Integration of datasets led to the identification of 92 co-regulated genes linked to fat deposition.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a57239488b21df87548050ahttps://doi.org/10.3390/ani16142172
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrative ATAC-Seq and RNA-Seq analysis identifies key genes for intramuscular fat content in Laiwu pigs2026
  2. 2Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis2024 · 26 citations
  3. 3Exploration of Genes Related to Intramuscular Fat Deposition in Xinjiang Brown Bulls2024
  4. 4Integration of multi-tissue transcriptomic data identifies key regulatory genes for porcine fat deposition2026
  5. 5Integrative transcriptomics and machine learning reveal key regulatory genes for meat quality traits in pigs2026