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July 15, 2026RespirationOpen Access

The Alteplase Dose Assessment for Pleural infection Therapy (ADAPT) Study – 3: Efficacy and safety of 1mg alteplase as a starting intrapleural dose

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Authors

ELEstee P. M. LauMDMichaela DonaghySFSam Faber

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Overview

Randomized trial evaluates the effectiveness of low-dose intrapleural therapy in patients with pleural infection, suggesting a safe approach.

Key Points

  • This study aims to determine the efficacy and safety of a starting intrapleural dose of 1mg tPA with 5mg DNase for pleural infection.
  • Consecutive patients with pleural infection received 1mg tPA and 5mg DNase intrapleurally.
  • Treatment success included dosage adjustments based on clinical discretion.
  • Total of 100 patients were enrolled in the trial.
  • 94% of patients were successfully treated and discharged without surgery.
  • Pleural fluid drainage increased from 238mL to 2013mL at 72 hours (p<0.0001).
  • Serum CRP levels decreased by 47.5% by day 5 (p<0.0001).

Cite This Study

Lau et al. (2026) studied this question.

synapsesocial.com/papers/6a5723c288b21df8754805b2https://doi.org/10.1159/000553096
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