Negative-pressure pulmonary edema

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Key Points

This research examines negative-pressure pulmonary edema as a significant but underdiagnosed condition following upper airway obstruction.
Analyzed incidence rates of negative-pressure pulmonary edema, estimating between 0.1% and 12%.
Identified symptoms related to upper airway obstruction events leading to respiratory distress.
Investigated pathophysiology involving hydrostatic stress and alveolar-capillary injury.
Patients displayed acute respiratory distress after obstruction, with symptoms like dyspnea and cyanosis.
Common causes of obstruction included postintubation edema, tumors, and foreign bodies.
True incidence rates likely higher than reported, with many cases underdiagnosed.

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Negative-pressure pulmonary edema arises after forceful inspiratory efforts in obstructed airways, indicating serious respiratory risk.

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Lemyze et al. (2026) studied this question.

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