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This review aims to discuss the role of CD36 in regulating metabolism under different hypoxic conditions and its implications for diseases.

July 15, 2026BiomoleculesOpen Access

CD36 as a Context-Dependent Regulator of Metabolic Switching in Acute and Chronic Hypoxia

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This review aims to discuss the role of CD36 in regulating metabolism under different hypoxic conditions and its implications for diseases.
Analyzed CD36 function and regulation in various tissue contexts during hypoxia.
Discussed signaling pathways influenced by hypoxia-inducible factor (HIF) and stress-activated kinases.
Reviewed implications of CD36 regulation for tissue-specific metabolic adaptations and disease outcomes.
In acute hypoxia, CD36 enhances rapid metabolic adaptation and inhibits lipotoxicity in cardiomyocytes.
Chronic hypoxia leads to CD36-mediated lipid uptake in hepatocytes and macrophages, promoting inflammation and tumor progression.
CD36 regulation varies across tissues, influencing cellular behaviors like migration and phagocytosis.

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Review highlights CD36's role in metabolic regulation during acute and chronic hypoxia, with implications for disease progression.

Popescu et al. (2026) studied this question.

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