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BACKGROUND: Randomized clinical trials are a mainstay of medical research, but have drawbacks including time and cost. Bayesian adaptive trials can improve the speed and efficiency of clinical trials and are an increasingly common trial design in critical care. However, the complexity of Bayesian adaptive trials may prevent clinicians from easily interpreting their results. RESEARCH QUESTION: Do intensivist physicians perceive, understand, and accept results from Bayesian adaptive clinical trials differently than results from traditional frequentist trials when presented with otherwise identical data? STUDY DESIGN AND METHODS: tests and ordinal logistic regressions. RESULTS: = .47). INTERPRETATION: Our results show that despite lower perceived understanding of Bayesian trials and skepticism about elements of their validity, no substantive differences were found in intensivist physician acceptance of Bayesian trial results compared with frequentist trial results. CHEST Critical Care 2026; 4(2):100264.
Malley et al. (Sat,) studied this question.