Key result
Exenatide 5 µg b.i.d. was associated with rapid worsening of renal impairment in a patient with Type 2 diabetes, with creatinine rising from 192 to 244 µmol/L over 4 weeks.
Why the study?
Does exenatide aggravate renal impairment in patients with Type 2 diabetes and pre-existing moderate renal disease?
Case Report (n=1)
Does exenatide aggravate renal impairment in patients with Type 2 diabetes and pre-existing moderate renal disease?
Exenatide may cause reversible worsening of renal function in patients with Type 2 diabetes and pre-existing moderate renal impairment, especially in the context of polypharmacy.
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May warrant caution with exenatide in moderate renal impairment; leaves open causality and generalizability.
Johansen et al. (2008) conducted a case report in Type 2 diabetes with renal impairment (n=1). Exenatide was evaluated on Renal function (creatinine levels and creatinine clearance). Exenatide 5 µg b.i.d. was associated with rapid worsening of renal impairment in a patient with Type 2 diabetes, with creatinine rising from 192 to 244 µmol/L over 4 weeks.
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