Why the study?
Does exenatide improve glycemic control and reduce bodyweight in Japanese patients with suboptimally controlled type 2 diabetes on oral therapy?
Population
179 Japanese patients with type 2 diabetes mellitus suboptimally controlled despite therapeutic doses of a…
Comparison
Exenatide 5 μg or 10 μg subcutaneously twice… vs Placebo subcutaneously twice daily added to oral…
Design
RCT, randomized, double-blind
Follow-up
24 weeks
Authors
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Supports adding exenatide to oral therapy for glycemic control in Japanese type 2 diabetes; extends GLP-1 RA efficacy data to East Asian populations.
Does exenatide improve glycemic control and reduce bodyweight in Japanese patients with suboptimally controlled type 2 diabetes on oral therapy?
Exenatide significantly improves glycemic control and reduces bodyweight when added to oral therapy in Japanese patients with type 2 diabetes, though it increases the risk of nausea and mild-to-moderate hypoglycemia.
Kadowaki et al. (2010) studied this question.
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