Key result
Three isoforms of the L-type voltage-dependent calcium channel beta subunit were cloned from a normal human heart, suggesting a different expression pattern than found in rat and rabbit hearts.
The study identifies three distinct isoforms of the L-type calcium channel beta subunit in the human heart, highlighting species-specific differences in expression patterns.
Three cardiac L-type Ca channel beta isoforms identified; leaves open their functional roles and therapeutic relevance.
We have cloned and sequenced cDNAs for three isoforms of the L-type voltage-dependent calcium channel beta subunit isolated from a normal human heart cDNA library. One of these subunits, designated beta a, hybridized with a 3.4-kb message, and the other two, designated beta b and beta c, hybridized with a message of approximately 1.9 kb. The presence of both of these latter two messages in human heart was confirmed by polymerase chain reaction methodology. Considering the differences between beta a and beta b/beta c, we find it likely that these messages may be encoded by two different gene sequences, beta a and beta b/beta c, and that the beta b/beta c sequence can be alternatively spliced in the 209-260 region. The data suggest that the human heart presents a different pattern of beta subunit expression from that found in the rat and rabbit heart.
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Collin et al. (1993) studied this question. Three isoforms of the L-type voltage-dependent calcium channel beta subunit were cloned from a normal human heart, suggesting a different expression pattern than found in rat and rabbit hearts.
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