Key result
Comorbid PH prevalence in exacerbated COPD varies regionally, peaking at ~67% in Asia.
Why the study?
Pulmonary hypertension is a COPD comorbidity linked to respiratory tract infections and exacerbations, but the prevalence of COPD exacerbations with comorbid PH needed determination.
Meta-Analysis
Yes
Comorbid pulmonary hypertension is highly prevalent in patients with exacerbated COPD, particularly in Asia and Europe, highlighting the importance of cardiovascular evaluation in this population.
Marked regional COPD-PH prevalence differences warrant awareness; leaves open drivers of variation and targeted research needs.
INTRODUCTION: The heart and lungs are interconnected organs. When one develops a pathology, it can interfere with the other’s function. One of the most common lung diseases is chronic obstructive pulmonary disease (COPD). Cardiovascular disorders are a major cause of COPD morbidity and mortality. Pulmonary hypertension (PH) is a COPD comorbidity associated with respiratory tract infections and COPD exacerbation. This systematic review and meta-analysis aimed to determine the prevalence of COPD exacerbations with comorbid PH.EVIDENCE ACQUISITION: This systematic review considered articles published from 2012 to 2022. English articles in the PubMed and Google Scholar electronic databases were searched using a series of keywords, including COPD, exacerbation, PH, and prevalence, combined using Boolean logic operators. The identified articles were meta-analyzed according to PRISMA guidelines.EVIDENCE SYNTHESIS: Six articles were included in the meta-analysis. A subgroup analysis considering each World Health Organization region indicated the prevalence of exacerbated COPD with comorbid PH was 66.7% (95% CI: 0-100%) in Asia, 65.1% (95% CI: 0-100%) in Europe, 10.4% (95% CI: 10.8-11.0%) in North America, and 3.6% (95% CI: 4.0-4.4%) in South America. The age of patients experiencing exacerbated COPD with comorbid PH was >60 years (62-72; 75±2). In addition, the prevalence of exacerbated COPD with PH varied between males and females among studies.CONCLUSIONS: Exacerbated COPD with comorbid PH was more common in Asia and Europe than in North and South America. Its prevalence was higher in patients aged >60 years and varied by sex and GOLD categories.
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OKTAVIANI et al. (2023) conducted a meta-analysis in Exacerbated chronic obstructive pulmonary disease with comorbid pulmonary hypertension. Comorbid pulmonary hypertension was evaluated on Prevalence of exacerbated COPD with comorbid pulmonary hypertension. The prevalence of exacerbated COPD with comorbid pulmonary hypertension varied by region, being highest in Asia (66.7%) and Europe (65.1%), and lower in North America (10.4%) and South America (3.6%).
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