Domino Synthesis of Furanyl‐1,2‐Diketones and One‐Pot Access to Furan‐Containing Quinoxalines

We report a domino protocol for the synthesis of furanyl 1,2‐diketones from dialkynyl‐1,6‐diols. This one‐step approach combines cyclization and oxidation, providing a streamlined and easy‐to‐perform synthetic route. The reaction has a broad substrate scope, accommodating both symmetrical and unsymmetrical 1,6‐diols with various substituents on the aromatic rings. Consistently high regioselectivity is observed, according to the electronic properties of aromatics. Additionally, the method is successfully applied to the one‐pot synthesis of substituted 2‐(furan‐2‐yl)quinoxalines, demonstrating its utility in the rapid construction of complex heterocyclic structures.