Clinicopathological Characteristics of Odontogenic Keratocysts in the Mexican Population

Background/Objectives: Our aim is to describe the clinical, imaging, and histopathological features of odontogenic keratocyst in a Mexican cohort. Methods: This is a retrospective, descriptive, and cross-sectional study. Clinical records and histopathology reports (2015–2025) from multiple laboratories were reviewed. Slides stained with hematoxylin and eosin were evaluated by pathologists using standardized criteria. Descriptive statistics were performed. Results: A total of 106 cases were included. Ages ranged from 10 to 86 years (mean 33.4 ± 17.7). There was a predominance of males (61/106; 57.5%). The most frequent location was the posterior mandible (49/106; 46.2%), followed by anterior mandible (30/106; 28.3%), posterior maxilla (19/106; 17.9%), and anterior maxilla (8/106; 7.5%). Most cases were asymptomatic (73/106; 68.9%). Association with an impacted tooth was documented in 37/106 (34.9%) and root resorption in 26/106 (24.5%). Satellite epithelial islands were observed in 8/106 (7.5%), satellite cysts in 17/106 (16.0%), and both findings in 4/106 (3.8%). Chronic inflammation was present in 62/106 (58.5%). Conclusions: In this Mexican series, odontogenic keratocyst predominated in males and, in the posterior mandible, was frequently asymptomatic, and showed satellite foci and chronic inflammation in a relevant proportion, reinforcing the need for clinical-imaging and histopathological correlation, as well as follow-up.