Key result
Regular antistreptococcal prophylaxis sees ~39% of children develop rheumatic heart disease at 5 years.
Why the study?
What are the sequelae and recurrence rates of acute rheumatic fever in children from North India receiving regular antistreptococcal prophylaxis?
Cohort (n=85)
What are the sequelae and recurrence rates of acute rheumatic fever in children from North India receiving regular antistreptococcal prophylaxis?
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With continuous antistreptococcal prophylaxis, the sequelae and recurrence of acute rheumatic fever in Indian children are similar to those in Western populations, with initial cardiac status being the major determinant of outcome.
Sanyal et al. (1982) conducted a cohort in Acute rheumatic fever (n=85). Regular antistreptococcal prophylaxis was evaluated on Rheumatic heart disease. Over a 5-year follow-up of children receiving regular antistreptococcal prophylaxis after a first attack of acute rheumatic fever, 38.8% developed rheumatic heart disease.
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