What does this research mean for the field?

GnRHa treatment effectively inhibits puberty, slows bone age maturation, and increases predicted adult height in girls with idiopathic central precocious puberty, with significantly greater height gains achieved when treatment is initiated before age 8. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

The aim is to assess the short-term outcomes of GnRHa therapy in girls diagnosed with ICPP after age 8.

May 5, 2025Gynecological EndocrinologyOpen Access

Efficacy of first-year GnRHa therapy in girls with idiopathic central precocious puberty diagnosed after age 8: a retrospective study

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Authors

MNMing-ming NiNanjing Children's Hospital SYShuting YangKunming Institute of Botany JSJieyu SunJiangsu Province Hospital

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Implication

Retrospective study evaluates height gain from GnRHa therapy in girls diagnosed after age 8, suggesting significant benefits with earlier treatment.

Key Points

The aim is to assess the short-term outcomes of GnRHa therapy in girls diagnosed with ICPP after age 8.
Retrospective review of 94 female patients treated with GnRHa from January 2018 to January 2021.
Patients divided into two groups based on age of treatment initiation: on or before age 8, and over age 8.
Hormonal parameters, BA/CA ratio, genital organ volume, PAH, and BMI assessed during treatment.
GnRHa treatment effectively inhibited puberty and increased PAH in both groups.
Group I showed significantly better PAH improvement, with 50% showing over a 5 cm increase compared to 25.9% in Group II.
No significant changes in BMI were recorded following treatment.

Cite This Study

Ni et al. (2025) studied this question.

synapsesocial.com/papers/6a58a91f7beebbcfc18086e0 https://doi.org/10.1080/09513590.2025.2500481

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Implication

Retrospective study evaluates height gain from GnRHa therapy in girls diagnosed after age 8, suggesting significant benefits with earlier treatment.

Efficacy of first-year GnRHa therapy in girls with idiopathic central precocious puberty diagnosed after age 8: a retrospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

Efficacy of first-year GnRHa therapy in girls with idiopathic central precocious puberty diagnosed after age 8: a retrospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

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