What is the clinical evidence from this study?

Study design: Other. Population: Myocardial ischemia (n=22). Intervention: Nerve growth factor (NGF) vs. Vehicle. Primary outcome: Changes in coronary vascular resistance (% delta CVR) to stellate stimulation (p=<.05).

What question did this study set out to answer?

This study investigates the protective effects of nerve growth factor (NGF) on sympathetic coronary innervation after ischemia.

July 16, 2026Circulation

Protective Role of Nerve Growth Factor Against Postischemic Dysfunction of Sympathetic Coronary Innervation

Q: What are the key findings of this study?

Exogenously infused NGF prevented the attenuation of coronary constriction to stellate stimulation after a 15-minute LAD occlusion compared to vehicle (P<0.05).

Q: What question did this study set out to answer?

This study investigates the protective effects of nerve growth factor (NGF) on sympathetic coronary innervation after ischemia.

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Key result

Exogenous NGF preserves sympathetic coronary constriction after brief LAD occlusion compared to vehicle.

P<.05
n=22

Why the study?

Does exogenous or endogenous nerve growth factor protect against ischemia-induced dysfunction of cardiac sympathetic nerves in a canine model?

Population

Anesthetized dogs undergoing 7- or 15-minute occlusion of the left anterior descending coronary artery (n=22)

Comparison

Nerve growth factor 10 ng.kg-1.min-1 infused… vs Vehicle infusion during 15-minute or 7-minute…

Design

Preclinical

Follow-up

Immediate post-reperfusion

Authors

TAToyohiko AbeUniversity of Iowa DMDonald A. MorganPreventive Cardiology DGDavid D. GuttermanRutgers, The State University of New Jersey

Discussion

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Implication

Exogenously infused and endogenously released nerve growth factor protects against postischemic neural stunning of sympathetic cardiac innervation in a canine model.

Key Points

This study investigates the protective effects of nerve growth factor (NGF) on sympathetic coronary innervation after ischemia.
In anesthetized dogs, stellate stimulation was performed to measure coronary vascular resistance before and after occlusions of the left anterior descending artery.
Dogs received infusions of NGF or vehicle during a 15-minute occlusion of the artery, and anti-NGF or vehicle during a 7-minute occlusion in separate experiments.
In the vehicle group, coronary vascular resistance increased significantly after a 15-minute occlusion (30 +/- 3% to 15 +/- 1%, P < .05); NGF infusion resulted in no such reduction.
In the anti-NGF group, coronary vascular resistance decreased after a 7-minute occlusion (39 +/- 8% to 17 +/- 2%, P < .05), while there was no significant change in the vehicle group (36 +/- 6% versus 37 +/- 7%, P = NS).

Structured PICO

Does exogenous or endogenous nerve growth factor protect against ischemia-induced dysfunction of cardiac sympathetic nerves in a canine model?

Population

22 anesthetized dogs undergoing 7- or 15-minute left anterior descending coronary artery occlusion to evaluate the effect of NGF on cardiac sympathetic nerves.

Intervention

Nerve growth factor (NGF) 10 ng.kg-1.min-1 infused into the LAD during 15-minute occlusion, or antibody to NGF (anti-NGF) 2 ng.kg-1.min-1 infused during 7-minute occlusion

Comparator

Vehicle infusion during 15-minute or 7-minute LAD occlusion

Outcome

Changes in coronary vascular resistance (% delta CVR) in response to bilateral stellate stimulation before and after release of LAD occlusionsurrogate

Main Result

p-value: p=<.05

Exogenously infused and endogenously released nerve growth factor protects against postischemic neural stunning of sympathetic cardiac innervation in a canine model.

Cite This Study

Abe et al. (1997) studied Myocardial ischemia (n=22). Nerve growth factor (NGF) vs. Vehicle was evaluated on Changes in coronary vascular resistance (% delta CVR) to stellate stimulation (p=<.05). Exogenously infused NGF prevented the attenuation of coronary constriction to stellate stimulation after a 15-minute LAD occlusion compared to vehicle (P<0.05).

synapsesocial.com/papers/6a58f679191b4970bd6cfa35 https://doi.org/10.1161/01.cir.95.1.213

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Implication

Exogenously infused and endogenously released nerve growth factor protects against postischemic neural stunning of sympathetic cardiac innervation in a canine model.

Protective Role of Nerve Growth Factor Against Postischemic Dysfunction of Sympathetic Coronary Innervation

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Protective Role of Nerve Growth Factor Against Postischemic Dysfunction of Sympathetic Coronary Innervation

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

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