Key result
CMR and echocardiography identify PFO as the cause of multifocal embolic MINOCA.
Why the study?
Embolic myocardial infarctions due to patent foramen ovale are rare, but identifying these patients is important to confirm their diagnosis and guide treatment.
Case Report (n=1)
No
Multi-modality imaging with cardiac MRI and echocardiogram is crucial for identifying intra-cardiac shunts like PFO in patients with multi-focal myocardial infarctions and non-obstructed coronaries.
May prompt multi-modality imaging in multi-focal MINOCA; leaves open whether PFO closure improves outcomes.
BACKGROUND: Occurrence of paradoxical coronary embolism is reported in up to 10-15% of all myocardial infarctions but embolic infarctions presumed to be as a result of a patent foramen ovale (PFO) are rare. Although rare, it is important to identify these patients as they need appropriate investigations to confirm their diagnosis and guide further treatment. CASE SUMMARY: We present the case of a gentleman with troponin positive chest pain with non-obstructed coronaries on invasive coronary angiogram. Subsequent cardiac magnetic resonance imaging (MRI) demonstrated multi-focal myocardial infarctions in several coronary artery territories. Further investigations including echocardiogram were performed in order to identify a cause and source of the embolic infarctions and led to the diagnosis of patent foramen ovale. The patient was treated as myocardial infarction with non-obstructed coronary arteries most likely due to embolic phenomena in the presence of a PFO. CONCLUSION: Multiple focal infarctions in multiple coronary artery territories should raise the suspicion of an intra-cardiac shunt. Multi-modality imaging with cardiac MRI and echocardiogram is important in correctly identifying any source of emboli and the diagnosis of any intra-cardiac shunt. Whilst PFO closure is a possible treatment for patients, considerations regarding risk stratification and local provisions needs to be taken into account. Patients should be referred to the appropriate subspecialist to ensure suitable long-term follow-up.
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Liang et al. (2022) conducted a case report in Myocardial infarction with non-obstructed coronary arteries (MINOCA) due to patent foramen ovale (n=1). Multi-modality imaging (Cardiac MRI and contrast echocardiography) was evaluated. Cardiac magnetic resonance imaging and echocardiography successfully identified a patent foramen ovale as the underlying cause of multi-focal embolic myocardial infarctions in a patient with MINOCA.
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