Key result
Alpha1 connexin is present from the heart tube stage (8.5 dpc) onward, with PKA and PKC activities fluctuating dynamically during early embryonic heart formation.
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Hypothesis-generating for connexin43 timing in murine cardiogenesis; leaves open any clinical relevance to human heart development.
Duncan et al. (2001) studied Developing mouse heart. Developmental stage was evaluated on Presence and phosphorylation state of alpha1 connexin, and endogenous activities of PKA and PKC. Alpha1 connexin is present from the heart tube stage (8.5 dpc) onward, with PKA and PKC activities fluctuating dynamically during early embryonic heart formation.
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