Key result
Larger preimplant QRS area (adjusted HR 0.93; 95% CI 0.88-0.98; p=0.011) and QRS area reduction were associated with a lower risk of heart failure hospitalization or death after CRT.
Why the study?
Current guideline indications do not accurately predict individual prognosis with CRT and up to 30% are nonresponders, prompting evaluation of digital ECG-derived QRS area preoperatively and during pacing.
Are larger preimplant QRS area and greater QRS area reduction associated with a reduced risk of heart failure hospitalization or death in patients receiving cardiac resynchronization therapy?
Population
445 patients receiving CRT implants at a tertiary care center in Sweden
Comparison
Preoperative and postimplant QRS area parameters
Design
Single-center retrospective cohort study
Follow-up
Median 2.7 years
Authors
Loading...
May aid post-CRT risk stratification; hypothesis-generating for prospective validation of QRS area-guided selection.
Cohort (n=445)
No
Are larger preimplant QRS area and greater QRS area reduction associated with a reduced risk of heart failure hospitalization or death in patients receiving cardiac resynchronization therapy?
Hazard Ratio: 0.93 (95% CI 0.88–0.98)
p-value: p=0.011
Larger preimplant QRS area and greater QRS area reduction following CRT implantation are associated with a lower risk of mortality and heart failure hospitalization.
Marinko et al. (2022) conducted a cohort in Heart failure (n=445). Larger preimplant QRS area and QRS area reduction was evaluated on Composite endpoint of heart failure hospitalization or death from any cause (adjusted HR 0.93, 95% CI 0.88-0.98, p=0.011). Larger preimplant QRS area (adjusted HR 0.93; 95% CI 0.88-0.98; p=0.011) and QRS area reduction were associated with a lower risk of heart failure hospitalization or death after CRT.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: