Key result
Aspirin 300 mg daily for two weeks significantly decreased malondialdehyde production from LDL following UVC irradiation compared to baseline (64.2 vs 89.6 nmol/mg LDL protein, P=0.029).
Why the study?
Does aspirin reduce the potential for oxidative modification of LDL in healthy normolipidaemic volunteers?
Does aspirin reduce the potential for oxidative modification of LDL in healthy normolipidaemic volunteers?
Answers are grounded in this paper and cite their sources.
Aspirin reduces the susceptibility of LDL to oxidative modification, suggesting an additional mechanistic pathway by which it may protect against atherosclerosis.
OBJECTIVE: To examine the effects of aspirin on the potential for oxidative modification of low density lipoprotein (LDL). DESIGN: Before and after trial. SETTING: University department of medicine within a district general hospital campus. PATIENTS: Ten healthy normolipidaemic volunteers drawn from laboratory and medical staff. INTERVENTIONS: Aspirin (enteric coated) 300 mg daily for two weeks. MAIN OUTCOME MEASURES: In vitro oxidation of LDL following ultraviolet C (UVC) irradiation with measurements made of malondialdehyde, conjugated dienes, and electrophoretic mobility. RESULTS: There was a significant decrease in malondialdehyde production from LDL modified by aspirin in vivo following exposure to UVC irradiation for 90 minutes, culminating in a 30% decrease by 240 minutes (mean (SD) 64.2 (9.12) v 89.6 (11.6) nmol/mg LDL protein, P = 0.029). These observations were borne out using LDL modified by aspirin in vitro. The UVC induced increase in relative electrophoretic mobility of LDL was also significantly reduced following aspirin treatment (mean (SD) 2.17 (0.16) v 2.66 (0.24), P = 0.012). CONCLUSIONS: Aspirin, both in vivo and in vitro, protects LDL against subsequent oxidative modification, providing an additional mechanism whereby aspirin may protect against atherosclerosis.
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Steer et al. (1997) studied Healthy normolipidaemic (n=10). Aspirin vs. Baseline (before treatment) was evaluated on Malondialdehyde production from LDL following UVC irradiation by 240 minutes (30% decrease, p=0.029). Aspirin 300 mg daily for two weeks significantly decreased malondialdehyde production from LDL following UVC irradiation compared to baseline (64.2 vs 89.6 nmol/mg LDL protein, P=0.029).
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