What is the clinical evidence from this study?

Study design: Other. Population: Atherosclerosis. Intervention: Aspirin vs. Control mice. Primary outcome: Vascular inflammation, plaque composition, and atherogenesis.

What question did this study set out to answer?

To evaluate the impact of low-dose aspirin on vascular inflammation, plaque composition, and atherogenesis in low-density lipoprotein receptor–deficient mice fed a high-fat diet.

September 3, 2002Circulation

Effect of Low-Dose Aspirin on Vascular Inflammation, Plaque Stability, and Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice

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Key result

In LDL receptor-deficient mice, low-dose aspirin reduced macrophage cells by 57% (P<0.05), increased smooth muscle cells by 77% (P<0.05), and increased collagen by 23% (P<0.05) in aortic lesions.

Why the study?

Does low-dose aspirin reduce vascular inflammation and atherogenesis in LDL receptor-deficient mice fed a high fat diet?

Population

LDL receptor-deficient mice fed a high fat diet

Comparison

Low-dose aspirin vs Control mice

Design

Preclinical

Authors

TCTillmann CyrusWashington University in St. Louis SSSyuan SungTranslational Therapeutics (United States)LZLei ZhaoFirst Affiliated Hospital of University of South China

Discussion

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Implication

Should not change clinical aspirin use; hypothesis-generating for plaque stabilization in murine atherosclerosis.

Key Points

To evaluate the impact of low-dose aspirin on vascular inflammation, plaque composition, and atherogenesis in low-density lipoprotein receptor–deficient mice fed a high-fat diet.
Administered low-dose aspirin to high-fat diet–fed LDL receptor–deficient mice and compared them to untreated control mice.
Assessed circulating levels and vascular expression of inflammatory cytokines, aortic nuclear factor kappaB (NF-κB) activity, lipid profiles, and histological markers of plaque composition.
Low-dose aspirin induced a significant decrease in circulating levels and vascular formation of sICAM-1, MCP-1, TNF-α, and IL-12p40 alongside reduced aortic NF-κB activity, with no effect on lipid levels.
Aspirin treatment significantly reduced total atherosclerosis extent, yielding a 57% reduction in plaque macrophages (P<0.05), a 77% increase in smooth muscle cells (P<0.05), and a 23% increase in collagen content (P<0.05).

Structured PICO

Does low-dose aspirin reduce vascular inflammation and atherogenesis in LDL receptor-deficient mice fed a high fat diet?

Population

LDL receptor-deficient mice fed a high fat diet

Intervention

Low-dose aspirin

Comparator

Control mice

Outcome

Vascular inflammation, plaque composition, and atherogenesissurrogate

In a murine model of atherosclerosis, low-dose aspirin suppresses vascular inflammation and promotes plaque stability.

Cite This Study

Cyrus et al. (2002) studied Atherosclerosis. Aspirin vs. Control mice was evaluated on Vascular inflammation, plaque composition, and atherogenesis. In LDL receptor-deficient mice, low-dose aspirin reduced macrophage cells by 57% (P<0.05), increased smooth muscle cells by 77% (P<0.05), and increased collagen by 23% (P<0.05) in aortic lesions.

synapsesocial.com/papers/6a0cfbb1b31ab1d6e01e768e https://doi.org/10.1161/01.cir.0000027816.54430.96

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Effect of Low-Dose Aspirin on Vascular Inflammation, Plaque Stability, and Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of Low-Dose Aspirin on Vascular Inflammation, Plaque Stability, and Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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