June 1, 2000Stroke
Indications for Early Aspirin Use in Acute Ischemic Stroke
Why the study?
Does early daily aspirin reduce the risk of further stroke or death in hospital in patients with suspected acute ischemic stroke?
Population
40,000 individual patients with suspected acute ischemic stroke from 2 large randomized trials (CAST and IST)
Comparison
Early daily aspirin vs Control
Design
Meta-analysis
Follow-up
2 to 4 weeks (in-hospital scheduled treatment period)
Authors
Discussion
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Member takes
Implication
Supports routine early aspirin in suspected acute ischemic stroke; reinforces Level 1 evidence for reducing early recurrence and death.
Structured PICO
Does early daily aspirin reduce the risk of further stroke or death in hospital in patients with suspected acute ischemic stroke?
P
Population
40,000 individual patients with suspected acute ischemic stroke from 2 large randomized trials (CAST and IST)
I
Intervention
Early daily aspirin
C
Comparator
Control
O
Outcome
Overall risk of further stroke or death in hospital during the scheduled treatment period (4 weeks in CAST, 2 weeks in IST)composite
Early aspirin use in acute ischemic stroke significantly reduces the risk of early recurrence and overall in-hospital death or further stroke, supporting its routine prompt administration.
Cite This Study
Sandercock et al. (2000) studied this question.