Why the study?
Does selective COX-2 inhibition or non-selective COX inhibition alter the rate of atherogenesis in fat-fed low density lipoprotein receptor knockout mice?
Population
Fat-fed low density lipoprotein receptor knockout mice
Design
Preclinical
Authors
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Hypothesis-generating for COX-1 involvement in murine atherogenesis; leaves open any effect of COX inhibitors on human plaque progression.
Does selective COX-2 inhibition or non-selective COX inhibition alter the rate of atherogenesis in fat-fed low density lipoprotein receptor knockout mice?
In a mouse model, non-selective COX inhibition reduced atherosclerosis while selective COX-2 inhibition did not accelerate it, implicating COX-1-derived prostanoids in atherogenesis.
Praticò et al. (2001) studied this question.
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