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November 1, 1981British Journal of Haematology

Platelet Adherence to Collagen: Role of Prostaglandin—Thromboxane Synthesis

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Why the study?

Does aspirin or indomethacin reduce the adherence of human platelets to collagen?

Population

Human platelets from normal subjects and subjects ingesting aspirin

Comparison

Aspirin and indomethacin vs Platelets not exposed to aspirin or indomethacin

Design

Preclinical

Authors

DCDale H. CowanBoston Children's Hospital

Discussion

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Implication

High-dose aspirin reduces platelet-collagen adherence; hypothesis-generating for prostaglandin pathways with no practice change warranted.

Structured PICO

Does aspirin or indomethacin reduce the adherence of human platelets to collagen?

P
Population
Human platelets from normal subjects and subjects ingesting aspirin
I
Intervention
Aspirin (1200 mg/day in vivo, or in vitro exposure) and indomethacin (in vitro)
C
Comparator
Platelets not exposed to aspirin or indomethacin
O
Outcome
Adherence of human platelets to collagensurrogate

Aspirin and indomethacin impair but do not fully inhibit platelet adherence to collagen, a process partly dependent on prostaglandin-thromboxane synthesis.

Cite This Study

Dale H. Cowan (1981) studied this question.

synapsesocial.com/papers/6a7dd45b1ec832c82ccdb1ffhttps://doi.org/10.1111/j.1365-2141.1981.tb07245.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Adherence to Collagen: Role of Plasma, ADP, and Divalent Cations1981 · 31 citations
  2. 2A Study of the Variable Response of Human Platelets to Collagen: Relation to Aspirin-induced Inhibition of Aggregation1973 · 32 citations
  3. 3Impaired Interaction (Adhesion-Aggregation) of Platelets with the Subendothelium in Storage-Pool Disease and after Aspirin Ingestion1975 · 111 citations
  4. 4The effect of salicylates on the hemostatic properties of platelets in man1968 · 539 citations
  5. 5Inhibition of collagen-induced platelet aggregation by normal plasma1971 · 25 citations