Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 1, 1970Biochemical JournalOpen Access

Effect of prostaglandin E1 alone and in combination with theophylline or aspirin on collagen-induced platelet aggregation and on platelet nucleotides including adenosine 3′:5′-cyclic monophosphate

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does prostaglandin E1 alone or combined with theophylline or aspirin inhibit collagen-induced platelet aggregation in human platelets?

Population

Human platelet-rich plasma labelled with [U-(14)C]adenine

Comparison

Prostaglandin E1 alone and in combination with… vs Untreated platelets or individual agents alone

Design

Preclinical

Authors

GBGe. BallRomax Technology (United Kingdom)GBG. G. BreretonGlaxoSmithKline (Germany)MFMary FulwoodGlaxoSmithKline (Germany)

Discussion

Loading...

Member takes

Overview

Does not support clinical antiplatelet use; leaves open translation of PGE1-theophylline synergy to human platelet inhibition.

Structured PICO

Does prostaglandin E1 alone or combined with theophylline or aspirin inhibit collagen-induced platelet aggregation in human platelets?

P
Population
Human platelet-rich plasma labelled with [U-(14)C]adenine
I
Intervention
Prostaglandin E1 alone and in combination with theophylline or aspirin
C
Comparator
Untreated platelets or individual agents alone
O
Outcome
Collagen-induced platelet aggregation and release of platelet ATP and ADPsurrogate

Prostaglandin E1 combined with theophylline or aspirin synergistically inhibits collagen-induced platelet aggregation in vitro.

Cite This Study

Ball et al. (1970) studied this question.

synapsesocial.com/papers/6a7e67f8fff18652e232fa92https://doi.org/10.1042/bj1200709
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of prostaglandin E1 on platelet behaviour in vitro and in vivo.1967 · 177 citations
  2. 2Effects of adrenaline on human blood platelets1967 · 285 citations
  3. 3Effect of some inhibitors of platelet aggregation on platelet nucleotides1969 · 38 citations
  4. 4Inhibition and Reversal of Platelet Aggregation by Methyl Xanthines1967 · 63 citations
  5. 5THE EFFECT OF ACETYLSALICYLIC ACID ON PLATELET FUNCTION1968 · 283 citations