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January 1, 1974Kitakantou igaku/Kitakantō IgakuOpen Access

Effect of Prostaglandin E1 on Platelet Function in Vitro and in Vivo

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Why the study?

Does prostaglandin E1 inhibit platelet aggregation and thrombus formation in vitro and in vivo?

Population

In vitro platelet preparations and in vivo experimental mature rabbits (both sexes, 2-3 kg)

Comparison

Prostaglandin E1 administered in vitro and in vivo vs Control (saline or no PGE1)

Design

Preclinical

Authors

NKNorio Kobayashi

Discussion

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Overview

PGE1's potent antiplatelet effects fail to curb experimental thrombus in rabbits; hypothesis-generating for in vivo antithrombotic limitations.

Structured PICO

Does prostaglandin E1 inhibit platelet aggregation and thrombus formation in vitro and in vivo?

P
Population
In vitro platelet preparations and in vivo experimental mature rabbits (both sexes, 2-3 kg)
I
Intervention
Prostaglandin E1 (PGE1) administered in vitro and in vivo (e.g., 10 µg/kg/min intravenous infusion)
C
Comparator
Control (saline or no PGE1)
O
Outcome
Platelet aggregation (in vitro induced by ADP, thrombin, or collagen; in vivo induced by ADP) and experimental thrombus formationsurrogate

PGE1 is a potent inhibitor of platelet aggregation in vitro and in vivo, though its rapid in vivo degradation may limit its efficacy in preventing experimental thrombus formation.

Cite This Study

Norio Kobayashi (1974) studied this question.

synapsesocial.com/papers/6a908255b71d06dae589ec95https://doi.org/10.2974/kmj1951.24.133
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of prostaglandin E1 on platelet behaviour in vitro and in vivo.1967 · 177 citations
  2. 2Release of a Platelet-Aggregating Substance (Adenosine Diphosphate) from Rabbit Blood Platelets Induced by Saline “Extract” of Tendons1963 · 181 citations
  3. 3The Effect of Prostaglandin E1 on Platelet Function in Vitro and in Vivo1970 · 88 citations
  4. 4Cyclic AMP and Platelet Function1972 · 213 citations
  5. 5Fine Structural Alterations Induced in Platelets by Adenosine Diphosphate1968 · 344 citations