Why the study?
Does prostaglandin E1 inhibit platelet aggregation and thrombus formation in vitro and in vivo?
Does prostaglandin E1 inhibit platelet aggregation and thrombus formation in vitro and in vivo?
PGE1 is a potent inhibitor of platelet aggregation in vitro and in vivo, though its rapid in vivo degradation may limit its efficacy in preventing experimental thrombus formation.
Answers are grounded in this paper and cite their sources.
PGE1's potent antiplatelet effects fail to curb experimental thrombus in rabbits; hypothesis-generating for in vivo antithrombotic limitations.
Effects of prostaglandin E1 (PGE1) on platelet function were investigated both in vitro and in vivo, and the following results were obtained : 1. PGE1 was a powerfull inhibitor of in-vitro platelet aggregation induced by ADP, thrombin or collagen. The inhibitory effect of PGE1 on ADP induced aggregation was 100-1, 000 times greater than that of adenosine.2. Theophylline inhibited the platelet aggregation induced by ADP and enhanced the inhibitory effect of PGE1. Exogeneous cyclic AMP also inhibited the ADP-and collagen induced aggregation. From these results, it was suggested that the effect of PGE1 on platelets might be mediated by an increase in the amount of cyclic AMP in platelets.3. PGE1inhibited the release of platelet factor 3 or serotonin from platelets.4. PGE1 produced a similar shape change in platelets by ADP.5. In experimental rabbits, PGE1 also inhibited the in-vivo aggregation of platelets, although there was no effect on the formation rate of stasis thrombus in the jugular vein or thrombus formation on the femoral artery with stenosing ligature by ellagic acid.
No takes yet. Share an insight, caveat, or question.
Norio Kobayashi (1974) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: