Why the study?
Does prostaglandin E1 inhibit platelet aggregation and thrombosis formation in vitro and in vivo?
Population
Blood taken from healthy volunteers (in vitro) and rabbits (in vivo)
Design
Preclinical
Authors
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PGE1 antiplatelet effects in animal models are hypothesis-generating; leaves open translation to human thrombosis prevention.
Does prostaglandin E1 inhibit platelet aggregation and thrombosis formation in vitro and in vivo?
Prostaglandin E1 demonstrates significant antiplatelet and antithrombotic effects in both in vitro human blood and in vivo rabbit models.
Emmons et al. (1967) studied this question.
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