Why the study?
Does Prostaglandin E1 inhibit platelet aggregation via a cAMP-independent pathway in human blood platelets?
Does Prostaglandin E1 inhibit platelet aggregation via a cAMP-independent pathway in human blood platelets?
This study demonstrates that Prostaglandin E1 can inhibit platelet aggregation through an alternative pathway that is independent of cyclic AMP.
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Suggests no immediate change to antiplatelet practice; leaves open cAMP-independent pathways in human platelets for confirmation.
Aggregation of human blood platelets induced by adenosine diphosphate or 1-epinephrine was inhibited when the platelets were suspended in plasma which had been previously exposed to an insolubilized omega-aminohexylagarose derivative of prostaglandin E1. This decrease of platelet aggregation was not accompanied by a change in the concentration of adenosine 3',5'-monophosphate (cyclic AMP) in platelets. The results demonstrate the existence of an alternative pathway independent of cyclic AMP for the inhibition of platelet aggregation by plasma.
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Sinha et al. (1978) studied this question.
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