January 1, 1986British Journal of PharmacologyOpen Access

The roles of prostaglandin endoperoxides, thromboxane A₂ and adenosine diphosphate in collagen‐induced aggregation in man and the rat

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Population

Platelets from man and rat

Design

Preclinical

Authors

HEH EmmsUniversity of Exeter GLG. P. LewisUniversity of Kentucky

Discussion

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Implication

Species differences limit rat-to-human extrapolation for aspirin; leaves open ADP-independent pathways in human aggregation.

Structured PICO

Population

Platelets from man and rat

Intervention

Aspirin, carboxyheptylimidazole (CHI), and creatine phosphate/creatine phosphokinase (CP/CPK) in vitro

Outcome

Platelet aggregation and thromboxane B2 (TxB2) formation induced by collagensurrogate

Collagen-induced platelet aggregation is largely dependent on ADP in man and entirely dependent on ADP in rats, with TxB2 formation likely dependent on prior ADP release or aggregation.

Cite This Study

Emms et al. (1986) studied this question.

synapsesocial.com/papers/6a7d8933d0946debe914fdca https://doi.org/10.1111/j.1476-5381.1986.tb10162.x

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The roles of prostaglandin endoperoxides, thromboxane A₂ and adenosine diphosphate in collagen‐induced aggregation in man and the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The roles of prostaglandin endoperoxides, thromboxane A₂ and adenosine diphosphate in collagen‐induced aggregation in man and the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider