Key result
Aspirin completely inhibited the collagen-induced release of adenosine diphosphate and partially suppressed the increase in glycolysis in human platelets.
Why the study?
Does aspirin prevent the release of adenosine diphosphate in human platelets?
Does aspirin prevent the release of adenosine diphosphate in human platelets?
Aspirin inhibits platelet activation by blocking the release of adenosine diphosphate and glucose transport across the platelet membrane.
Answers are grounded in this paper and cite their sources.
May inform aspirin's antiplatelet mechanism in vitro; leaves open translation to clinical outcomes.
Incubation of human platelets with aspirin inhibited glycolysis and produced a fall in the concentration of adenosine triphosphate. When platelets were exposed to collagen there was an increase in glycolysis and release of adenosine diphosphate. Prior incubation of the platelets with aspirin for 5 minutes did not totally suppress the increase in glycolysis after exposure to collagen but completely inhibited the collagen-induced reaction of the release of adenosine diphosphate. It is suggested that aspirin acts on human platelets by inhibiting both release of adenosine diphosphate and the transport of glucose across the platelet membrane.
No takes yet. Share an insight, caveat, or question.
Doery et al. (1969) studied this question. Aspirin was evaluated on Platelet glycolysis and release of adenosine diphosphate. Aspirin completely inhibited the collagen-induced release of adenosine diphosphate and partially suppressed the increase in glycolysis in human platelets.
Synapse has enriched 10 related papers. Consider them for comparative context: