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October 1, 1978Journal of Clinical InvestigationOpen Access

Effect of Aspirin on Thrombin-Induced Adherence of Platelets to Cultured Cells from the Blood Vessel Wall

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Population

In vitro model usingCr-labeled platelets and monolayers of cultured human endothelial, fibroblast, and…

Comparison

Aspirin (1-2 mM and 0.1 mM) vs Untreated monolayers

Design

Preclinical

Authors

RCR L CzervionkeJHJohn C. HoakGFGlenna L. Fry

Discussion

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Overview

High-dose aspirin may enhance platelet adherence in vitro; leaves open translation to clinical dosing or in vivo thrombosis.

Structured PICO

P
Population
In vitro model using (51)Cr-labeled platelets and monolayers of cultured human endothelial, fibroblast, and smooth muscle cells
I
Intervention
Aspirin (1-2 mM and 0.1 mM)
C
Comparator
Untreated monolayers
O
Outcome
Thrombin-induced adherence of platelets to cultured cellssurrogate

In vitro, high concentrations of aspirin (1-2 mM) enhance thrombin-induced platelet adherence to endothelial cells, while lower concentrations (0.1 mM) inhibit platelet malonaldehyde production without impairing endothelial anti-adherence properties.

Cite This Study

Czervionke et al. (1978) studied this question.

synapsesocial.com/papers/6a83d4b8d65172829ee664dahttps://doi.org/10.1172/jci109197
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Sequestration in Man. I. Methods*1964 · 818 citations
  2. 2Inhibition of platelet prostaglandin synthetase by oral aspirin.1978 · 557 citations
  3. 3The effect of salicylates on the hemostatic properties of platelets in man1968 · 539 citations
  4. 4A Simple Nonradioisotope Technic for the Determination of Platelet Life-Span1975 · 244 citations
  5. 5THE SMOOTH MUSCLE CELL1971 · 1,573 citations