Why the study?
Does aspirin treatment of endothelial cells increase thrombin-induced platelet adherence by inhibiting prostacyclin production?
Population
Cultured endothelial cells from the umbilical vein
Comparison
Aspirin treatment in the presence of thrombin… vs Untreated endothelial monolayers
Design
Preclinical
Authors
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Should not alter aspirin use; leaves open translation of endothelial prostacyclin inhibition to clinical thrombosis risk.
Does aspirin treatment of endothelial cells increase thrombin-induced platelet adherence by inhibiting prostacyclin production?
High-dose aspirin inhibits endothelial prostacyclin production, leading to increased thrombin-induced platelet adherence in vitro.
Czervionke et al. (1979) studied this question.
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