Key result
Capsaicin administration into the renal interstitium triggers sympathetic activation mediated via IL-1β in the paraventricular nucleus of the hypothalamus.
Why the study?
Inflammatory pain is a maladaptive consequence of inflammatory stimulation of the afferent somatosensory system, prompting the establishment of a model to test spinal cord responses to stimulation.
This study establishes a neuroglial primary culture model of the rat superficial dorsal horn to investigate central processing of afferent pathways.
Answers are grounded in this paper and cite their sources.
Renal capsaicin may drive sympathetic activation via PVN IL-1β in rats; leaves open translation to human cardiorenal disease.
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Rodionova et al. (2020) conducted an editorial in Sympathetic excitatory reflex. Capsaicin administration into the renal interstitium triggers sympathetic activation mediated via IL-1β in the paraventricular nucleus of the hypothalamus.
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