Isotelluroureas (ITeUs) have recently been introduced as a novel class of highly nucleophilic Lewis base catalysts. Herein, we systematically screened them for their potential to facilitate C1 ammonium enolate transformations and directly compared them to their lighter chalcogen‐analogs, the corresponding well‐established isothioureas (ITUs) and isoselenoureas (ISeUs). We found ITeUs being well‐suited for a variety of C1 ammonium enolate‐based α‐C─C bond forming reactions and in the majority of applications, the use of ITeUs allowed for significantly shorter reaction times compared to the use of ITUs or ISeUs, accompanied with often higher levels of enantioselectivities too.
Khorasani et al. (Wed,) studied this question.
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