Incidence and factors associated with premature ovarian insufficiency: a population-based cohort study

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This study aims to determine the incidence of premature ovarian insufficiency (POI) and identify associated factors among women in Ontario.
Population-based cohort study including women aged ≤ 39 years in Ontario from 1995 to 2019.
Incidence rates were calculated using administrative health data and census figures, with follow-up until POI diagnosis or age 40.
Associations between clinical factors and POI were analyzed using age-adjusted modified Poisson regression.
168,173 women developed POI, with an overall incidence rate of 389.4 per 100,000 person-years.
The incidence of non-iatrogenic POI was 351.4 per 100,000 person-years, with endometriosis significantly associated (IRR 3.45, 95% CI 3.39-3.52).
Surgically induced POI incidence declined from 60 to 20 per 100,000 person-years from 1995 to 2019.

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Population-based cohort study assesses the rising incidence of premature ovarian insufficiency in women with specific health factors.

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Macintyre et al. (2026) studied this question.

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