What question did this study set out to answer?

The central aim is to develop a biocatalytic method for synthesizing tertiary amines using engineered enzymes.

An Engineered Enzyme Catalyzing Tandem Reductive Aminations for Synthesizing Tertiary Amines

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Engineered enzyme facilitates sustainable tertiary amine synthesis, indicating a breakthrough in biocatalysis.

The central aim is to develop a biocatalytic method for synthesizing tertiary amines using engineered enzymes.
Engineering of wild-type imine reductase into a tandem aminase for reductive amination.
Utilization of x-ray crystallography and mutagenesis for mechanistic investigation.
One-pot synthesis of tertiary amines from primary amine precursors.
The tandem aminase enables synthesis of hundreds of tertiary amines from available amine precursors.
Alterations in enzyme-pocket design significantly enhance the second-step amination activity.
The new approach offers precise stereochemical control over multiple stereocenters.

Ma et al. (2026) studied this question.

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