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July 17, 2026PLoS ONEOpen Access

Multiple comorbidities and male sex are linked to higher 180-day readmission risk in older dementia patients.

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Why the study?

People living with dementia face an increased risk of multiple hospital admissions, making reducing readmission rates a key clinical priority.

What are the determinants of hospital readmission within 180 days and subsequent 1-year mortality in older adults with dementia?

Population

30,527 patients > 65y with dementia and an acute general hospital admission in England

Comparison

Determinants of readmission and post-readmission mortality

Design

Retrospective cohort study using linked electronic health records

Follow-up

180 days of discharge for readmission, and one year of readmission for mortality

Key result

Multiple long-term conditions and male sex were positively associated with hospital readmission within 180 days in older adults with dementia, who experienced an overall readmission rate of 40.5%.

Authors

BBBria BrowneIRImogen RogersKAKhalid Ali

Discussion

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Overview

Multimorbidity strongly predicts 180-day readmission in dementia; hypothesis-generating for targeted interventions pending prospective validation.

Key Points

  • This study aims to identify factors influencing hospital readmissions and mortality risk in older adults with dementia.
  • Retrospective cohort study utilizing Clinical Practice Research Datalink.
  • Included patients over 65 with dementia and a prior acute hospital admission.
  • Employed stepwise logistic regression for readmission and Cox regression for mortality analysis.
  • Out of 30,527 patients, 12,351 (40.5%) were readmitted within 180 days.
  • Being male and having multiple long-term conditions were associated with higher readmission rates (p<0.05).
  • Age, sex, and number of long-term conditions were significant predictors of mortality risk in the readmitted group.

Study Design

Type

Cohort (n=30,527)

Multicenter

Yes

Structured PICO

What are the determinants of hospital readmission within 180 days and subsequent 1-year mortality in older adults with dementia?

P
Population
30,527 adults >65 years old with dementia and a recent acute hospital admission, evaluated for determinants of 180-day readmission and 1-year mortality.
O
Outcome
Readmission to hospital within 180 days of discharge, and mortality within one year of readmissionhard clinical

Multiple long-term conditions are the strongest determinant of hospital readmission within 180 days in older adults with dementia.

Cite This Study

Browne et al. (2026) conducted a cohort in dementia (n=30,527). Clinical and demographic factors (e.g., multiple long-term conditions) was evaluated on Readmission to hospital within 180 days of discharge. Multiple long-term conditions and male sex were positively associated with hospital readmission within 180 days in older adults with dementia, who experienced an overall readmission rate of 40.5%.

synapsesocial.com/papers/6a59c63fa58755010b47174dhttps://doi.org/10.1371/journal.pone.0351331
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