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July 17, 2026Particle and Fibre ToxicologyOpen Access

Black phosphorus nanomaterials induce hepatic lipid metabolism disorders by triggering oxidative stress and mitochondrial dysfunction

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Authors

SZSihao ZhuFRFengkai RuanYZYan Zhang

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Overview

Randomized trial investigates hepatic lipid metabolism disruptions in mice due to black phosphorus nanomaterials, suggesting biosafety concerns.

Key Points

  • The research aims to evaluate the hepatotoxic effects of black phosphorus nanomaterials (BPNM) on lipid metabolism and to understand the underlying mechanisms.
  • 28-day daily oral administration of BPNM at doses of 0.1 and 1 mg/kg in mice
  • Assessment of hepatic lipid accumulation, insulin sensitivity, and inflammatory responses
  • RNA-sequencing to analyze oxidative stress and mitochondrial dysfunction
  • Mice showed reduced insulin sensitivity and increased inflammatory responses after BPNM exposure
  • Significant lipid accumulation was observed, indicated by decreased serum triglycerides and VLDL levels
  • In vitro studies revealed restoration of mitochondrial function when treated with ROS scavenger and ATP supplementation

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6a59c693a58755010b471bd8https://doi.org/10.1186/s12989-026-00695-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Accumulation, distribution, and toxicity of black phosphorus nanomaterials across biological systems: a critical review2026
  2. 2Black phosphorus in neurological disorders: Current therapeutic applications, mechanisms, and future prospects2026
  3. 3Redox-regulating black phosphorus quantum dots: Mechanistic insights, biomedical applications, and ocular therapeutic perspectives2026
  4. 4Unveiling the mechanisms of black phosphorus nanosheets-induced viable but non-culturable state in Bacillus tropicus2024
  5. 5A Stable Metal–Polyphenol Network‐Functionalized Black Phosphorus Nanoplatform for Multidrug‐Loading and Controllable Chemo–Photothermal Therapy2026