Novel Imaging Approaches to Cardiac Manifestations of Systemic Inflammatory Diseases

Q: What is the clinical evidence from this study?

Study design: Review. Population: Systemic inflammatory diseases with cardiac manifestations. Intervention: Advanced multimodality cardiac imaging.

Q: What does this research mean for the field?

Advanced multimodality cardiac imaging improves diagnostic precision for screening, early diagnosis, and noninvasive monitoring of cardiac involvement in systemic inflammatory diseases. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Brittany Weber; Julie J. Paik; Ayaz Aghayev; Allan L. Klein; Sophie Mavrogeni; Paul B. Yu; Monica Mukherjee

doi:10.1016/j.jacc.2023.09.819

November 1, 2023Journal of the American College of CardiologyOpen Access

Novel Imaging Approaches to Cardiac Manifestations of Systemic Inflammatory Diseases

View Full Paper

Ask AI

Bookmark

Share

Key result

Advanced multimodality cardiac imaging improves early detection and risk stratification in systemic inflammatory diseases.

Why the study?

Systemic inflammatory syndromes contribute to elevated atherosclerotic risk and cardiovascular disease, and novel multimodality imaging may improve diagnostic precision for screening and monitoring.

Does advanced multimodality cardiac imaging improve the detection and monitoring of cardiac manifestations in patients with systemic inflammatory diseases?

Key Points

To review the common cardiovascular manifestations of immune-mediated systemic inflammatory diseases and evaluate the clinical and investigational utility of advanced multimodality cardiac imaging.
Conducted a comprehensive scientific statement review on behalf of the American College of Cardiology Cardiovascular Imaging Leadership Council.
Evaluated cardiovascular phenotypes and multimodality imaging applications across conditions including rheumatoid arthritis, psoriatic arthritis, and spondyloarthritis.
Patients with rheumatoid arthritis display a 1.5- to 2.0-fold increased risk of developing coronary artery disease compared with the general population.
Aortic root inflammation, dilatation, and aortic regurgitation are observed in up to 80% of patients with ankylosing spondylitis.
Across systemic inflammatory arthritic diseases, accelerated atherosclerosis results in a 2-fold higher incidence of adverse cardiovascular events.

Structured PICO

Does advanced multimodality cardiac imaging improve the detection and monitoring of cardiac manifestations in patients with systemic inflammatory diseases?

P

Population

Patients with systemic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, sarcoidosis) at risk for cardiovascular manifestations.

I

Intervention

Advanced multimodality cardiac imaging (echocardiography, CMR, cardiac CT, PET)

This scientific statement highlights the critical role of multimodality imaging in identifying and managing the elevated cardiovascular risk and specific cardiac manifestations associated with systemic inflammatory diseases.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Supports multimodality imaging for detection in systemic inflammatory diseases; extends observational data but leaves open need for prospective validation.

Abstract

Derangements in the innate and adaptive immune responses observed in systemic inflammatory syndromes contributes to unique elevated atherosclerotic risk and incident cardiovascular disease. Novel multimodality imaging techniques may improve diagnostic precision for the screening and monitoring of disease activity. The integrated application of these technologies lead to earlier diagnosis and noninvasive monitoring of cardiac involvement in systemic inflammatory diseases that will aid in preclinical studies, enhance patient selection, and provide surrogate endpoints in clinical trials, thereby improving clinical outcomes. We review the common cardiovascular manifestations of immune-mediated systemic inflammatory diseases and address the clinical and investigational role of advanced multimodality cardiac imaging.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Weber et al. (2023) conducted a review in Systemic inflammatory diseases with cardiac manifestations. Advanced multimodality cardiac imaging was evaluated. Advanced multimodality cardiac imaging plays a crucial role in the early detection, risk stratification, and monitoring of cardiovascular manifestations in patients with systemic inflammatory diseases.

synapsesocial.com/papers/6a5a47ea441a215ba307638c https://doi.org/10.1016/j.jacc.2023.09.819

View Full Paper

Ask AI

Bookmark

Share

Novel Imaging Approaches to Cardiac Manifestations of Systemic Inflammatory Diseases

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Novel Imaging Approaches to Cardiac Manifestations of Systemic Inflammatory Diseases

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading