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“The benefits of combination strategies with three or four BP-lowering drugs at low doses in the same pill have been investigated over the last years as a potentially effective approach to achieve BP therapeutic goals while reducing side effects and improving adherence.”
“Most patients with hypertension are started on monotherapy, and many remain on monotherapy even when blood pressure control is inadequate, due to factors such as treatment inertia and concerns about adverse effects and costs. Studies of individual antihypertensive medications suggest that benefits outweigh side effects at low medication doses.”
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Nolde et al. (2023) studied this question.
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