Key result
Smoking, beta-blocker use, and uncontrolled blood pressure were independently associated with higher odds of uncontrolled LDL-C in outpatients with myocardial infarction.
Why the study?
Discrepancies exist regarding factors influencing LDL-C control in patients with myocardial infarction, and identifying these predictors is essential for guiding future interventions to enhance health outcomes.
Cross-Sectional (n=333)
No
Odds Ratio: 2.006 (95% CI 1.054–3.816)
p-value: p=0.034
A high proportion of post-MI outpatients in Jordan have uncontrolled LDL-C, which is independently associated with smoking, beta-blocker use, and uncontrolled blood pressure, highlighting a need for comprehensive secondary prevention strategies.
May inform targeted secondary prevention in post-MI outpatients; hypothesis-generating and needs prospective confirmation before changing practice.
Discrepancies in factors influencing low-density lipoprotein cholesterol (LDL-C) control in patients with myocardial infarction have been documented in existing literature. Assessing LDL-C control and the associated factors is a crucial initial measure for guiding future interventions aimed at enhancing health outcomes in patients with myocardial infarction (MI). This study aimed to evaluate LDL-C control status and explore the predictors of uncontrolled LDL-C in patients with myocardial infarction. Data were collected by a research pharmacist from medical records, including sociodemographic and clinical characteristics, comorbidities, prescribed medications, and biomedical parameters such as LDL-C levels among patients attending an outpatient cardiology clinic. The validated Arabic versions of the 4-item medication adherence scale and the medication beliefs questionnaire were used to evaluate medication adherence and beliefs, respectively. Binary logistic regression was implemented to investigate the predictors of LDL-C control. The results showed most of the patients (n = 255) had uncontrolled LDL-C (76.6%). Regression results revealed that smoking (OR= 2.006; 95% CI: 1.054–3.816; P = 0.034), receiving beta blockers (OR=2.211; 95% CI: 1.024–4.775; P = 0.043), and having uncontrolled blood pressure (OR=1.940; 95% CI: 1.069–3.520; P = 0.029) were independently associated with higher odds of uncontrolled LDL-C. In conclusion, in MI patients with poor LDL-C control, lowering the risk of cardiac complications and improving health outcomes require the development of focused and efficient LDL-C level management strategies. Achieving this goal will require putting strategies like smoking cessation counselling into practice and improving BP control.
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Jarab et al. (2026) conducted a cross-sectional in Myocardial Infarction (n=333). Smoking vs. Non-smokers was evaluated on Uncontrolled LDL-C (>70 mg/dL) (OR 2.006, 95% CI 1.054-3.816, p=0.034). Smoking, beta-blocker use, and uncontrolled blood pressure were independently associated with higher odds of uncontrolled LDL-C in outpatients with myocardial infarction.
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