Key result
Routine oxygen after acute stroke yields ~2.9-fold higher odds of early neurological improvement vs. room air.
RCT (n=289)
randomized
Answers are grounded in this paper and cite their sources.
Randomized trial evaluates impact of oxygen supplementation on neurological function in acute stroke, suggesting potential benefits.
UNLABELLED: Mild hypoxia is common after stroke and associated with poor long-term outcome. Oxygen supplementation could prevent hypoxia and improve recovery. A previous study of routine oxygen supplementation showed no significant benefit at 7 and 12 months. This pilot study reports the effects of routine oxygen supplementation for 72 hours on oxygen saturation and neurological outcomes at 1 week after a stroke. METHODS: Patients with a clinical diagnosis of acute stroke were recruited within 24 h of hospital admission between October 2004 and April 2008. Participants were randomized to oxygen via nasal cannulae (72 h) or control (room air, oxygen given only if clinically indicated). Clinical outcomes were assessed by research team members at 1 week. Baseline data for oxygen (n = 148) and control (n = 141) did not differ between groups. RESULTS: The median (interquartile range) National Institutes of Health Stroke Scale (NIHSS) score for the groups at baseline was 6 (7) and 5 (7) respectively. The median Nocturnal Oxygen Saturation during treatment was 1.4% (0.3) higher in the oxygen than in the control group (p<0.001) during the intervention. At 1 week, the median NIHSS score had reduced by 2 (3) in the oxygen and by 1 (2) in the control group. 31% of participants in the oxygen group and 14% in the control group had an improvement of ≥4 NIHSS points at 1 week doubling the odds of improvement in the oxygen group (OR: 2.9). CONCLUSION: Our data show that routine oxygen supplementation started within 24 hours of hospital admission with acute stroke led to a small, but statistically significant, improvement in neurological recovery at 1 week. However, the difference in NIHSS improvement may be due to baseline imbalance in stroke severity between the two groups and needs to be confirmed in a larger study and linked to longer-term clinical outcome. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN12362720; European Clinical Trials Database 2004-001866-41.
No takes yet. Share an insight, caveat, or question.
Roffe et al. (2011) conducted an RCT in acute stroke (n=289). Routine oxygen supplementation vs. room air (oxygen only if clinically indicated) was evaluated on improvement of ≥4 NIHSS points at 1 week (OR 2.9). Routine oxygen supplementation for 72 hours after acute stroke improved the odds of a ≥4 point NIHSS improvement at 1 week compared to room air.
Synapse has enriched 10 related papers. Consider them for comparative context: