Key result
Vagal baroreflex sensitivity to blood pressure increments during the Valsalva maneuver was inversely related to age, with age, BRS_v↓, and phase IV magnitude predicting 47% of its variance.
Why the study?
How do vagal baroreflex sensitivity responses to blood pressure increments and decrements during the Valsalva maneuver relate to age and each other in normal subjects?
Observational (n=187)
How do vagal baroreflex sensitivity responses to blood pressure increments and decrements during the Valsalva maneuver relate to age and each other in normal subjects?
Answers are grounded in this paper and cite their sources.
Both vagal baroreflex sensitivity to blood pressure increments and decrements become blunted with increasing age and are interrelated.
INTRODUCTION: The Valsalva maneuver (VM) is used widely to quantify the sensitivity of the vagal baroreflex loop (vagal baroreflex sensitivity, BRS_v), but most studies have focused on the heart rate (HR) response to blood pressure (BP) decrement (BRS_v↓), even though the subsequent response to an increment in BP after the VM (BRS_v↑) is important and different. METHODS: We evaluated recordings of HR and BP in 187 normal subjects during the VM and determined both BRS_v↑, as determined by relating HR to the BP increase after phase III and BRS_v↓. RESULTS: BRS_v↑ was related inversely to age. In addition, BRS_v↓, age, and magnitude of phase IV were independent predictors of BRS_v↑ in a multivariate model, accounting for 47% of the variance of BRS_v↑. CONCLUSIONS: The results indicate that both BRS_v↑ and BRS_v↓ become blunted with increasing age and that these indices relate to each other.
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Wada et al. (2014) conducted an observational in Healthy (normal subjects) (n=187). Valsalva maneuver was evaluated on Vagal baroreflex sensitivity to blood pressure increment (BRS_v↑) and decrement (BRS_v↓). Vagal baroreflex sensitivity to blood pressure increments during the Valsalva maneuver was inversely related to age, with age, BRS_v↓, and phase IV magnitude predicting 47% of its variance.
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