Key result
The transradial approach significantly reduced bleeding rates compared to the transfemoral approach, which was a strong predictor of TIMI major or minor bleedings (OR 6.67; 95% CI 1.72-25; P=0.006).
Why the study?
Does the transradial approach reduce bleeding in patients with acute coronary syndromes undergoing urgent PCI with GPIIb/IIIa inhibitors compared to the transfemoral approach?
Cohort (n=531)
Does the transradial approach reduce bleeding in patients with acute coronary syndromes undergoing urgent PCI with GPIIb/IIIa inhibitors compared to the transfemoral approach?
Odds Ratio: 6.67 (95% CI 1.72–25)
p-value: p=0.006
The transradial approach significantly reduces access site bleeding complications compared to the transfemoral approach in patients undergoing urgent PCI with GPIIb/IIIa inhibitors for acute coronary syndromes.
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May lower bleeding in GPI-treated urgent PCI; hypothesis-generating and requires randomized confirmation before practice change.
Carlo et al. (2009) conducted a cohort in Acute coronary syndromes (n=531). Transradial approach vs. Transfemoral approach was evaluated on Rate of bleedings, graded according to the Thrombolysis in Myocardial Infarction (TIMI) classification (OR 6.67, 95% CI 1.72-25, p=0.006). The transradial approach significantly reduced bleeding rates compared to the transfemoral approach, which was a strong predictor of TIMI major or minor bleedings (OR 6.67; 95% CI 1.72-25; P=0.006).
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