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December 18, 2003Catheterization and Cardiovascular InterventionsOpen Access

Comparison of transradial vs. transfemoral approach in the treatment of acute myocardial infarction with primary angioplasty and abciximab

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Why the study?

Does the transradial approach improve clinical outcomes and reduce bleeding compared to the transfemoral approach in patients with acute myocardial infarction treated with primary angioplasty and abciximab?

Population

119 consecutive patients with acute myocardial infarction undergoing primary angioplasty and receiving the…

Comparison

Transradial approach for primary angioplasty vs Transfemoral approach for primary angioplasty

Design

Cohort, None (nonrandomized study)

Follow-up

1-month

Key result

Transradial access for primary angioplasty in AMI had similar freedom from major cardiac events (97% vs 94.5%, P=0.19) and fewer bleeding complications (0% vs 5.5%, P=0.03) than transfemoral access.

Authors

PFPhilippe FrançoisFLFabrice LarrazetTMT Meziane

Discussion

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Overview

Radial access was associated with shorter stay but higher radiation; leaves open net benefit in primary PCI with abciximab.

Study Design

Type

Cohort (n=119)

Structured PICO

Does the transradial approach improve clinical outcomes and reduce bleeding compared to the transfemoral approach in patients with acute myocardial infarction treated with primary angioplasty and abciximab?

P
Population
119 consecutive patients with acute myocardial infarction undergoing primary angioplasty with abciximab, followed for 1 month.
E
Exposure
Transradial approach for primary angioplasty
C
Comparator
Transfemoral approach for primary angioplasty
O
Outcome
Freedom from major cardiac events at 1-month follow-upcomposite

Main Result

Absolute Event Rate: 97% vs 94.5%

p-value: p=0.19

In patients with acute myocardial infarction undergoing primary angioplasty with abciximab, transradial access reduces access site bleeding complications and hospital length of stay compared to transfemoral access, despite higher radiation exposure.

Limitations

  • Nonrandomized study design

Cite This Study

François et al. (2003) conducted a cohort in Acute myocardial infarction (n=119). Transradial approach vs. Transfemoral approach was evaluated on Freedom from major cardiac events at 1-month follow-up (p=0.19). Transradial access for primary angioplasty in AMI had similar freedom from major cardiac events (97% vs 94.5%, P=0.19) and fewer bleeding complications (0% vs 5.5%, P=0.03) than transfemoral access.

synapsesocial.com/papers/6a6c063ab47c2e26b42435a8https://doi.org/10.1002/ccd.10675
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transradial approach in patients with ST-elevation myocardial infarction treated with abciximab results in fewer bleeding complications: data from EUROTRANSFER registry2010 · 35 citations
  2. 2Comparison between femoral access versus radial access in primary percutaneous coronary interventions2021
  3. 3Safety and feasibility of emergent percutaneous coronary intervention with the transradial access in patients with acute myocardial infarction2007 · 44 citations
  4. 4Comparison between Trans-Radial Versus Trans-Femoral Arterial Access in Primary Percutaneous Coronary Intervention2021
  5. 5Transradial approach for coronary angioplasty in the setting of acute myocardial infarction: A dual‐center registry2002 · 102 citations