Growth hormone deficiency was significantly associated with higher adipose (pro)renin receptor mRNA expression after adjustment for obesity (β 2.257, 95% CI 0.367-4.417, P=0.023).
Observational (n=15)
Adipose (pro)renin receptor expression is increased in patients with growth hormone deficiency, suggesting a potential mechanism for fat accumulation in this population.
Mean Difference: 2.257 (95% CI 0.367–4.417)
p-value: p=0.023
Fat accumulation leads to obesity, which increases the risk of cardiovascular diseases. Recent studies have shown that adipose (pro)renin receptor (PRR) may play a role in fat accumulation, and we previously reported increased adipose (P)RR expression in growth hormone (GH) deficiency in mice; however, the association between human adipose (P)RR expression and GH deficiency remains unclear. In this prospective study, abdominal subcutaneous adipose tissue was collected during pituitary surgery in patients with non-functioning hypothalamic-pituitary masses, and the associations between adipose (P)RR mRNA expression, determined using reverse transcription-polymerase chain reaction, and GH deficiency and other clinical parameters were investigated. Fifteen patients (5 craniopharyngioma, 4 non-functioning pituitary neuroendocrine tumor, 4 Rathke’s cleft cyst, and 2 other diseases) (mean age, 53 ± 17 years; male sex, 3 20%; and mean body mass index BMI, 24.8 ± 4.3 kg/m 2 ; GH deficiency, 8 53%) were included. Adipose (P)RR mRNA expression was significantly higher in patients with GH deficiency ( P = 0.009) compared to those without, but was not significantly associated with other pituitary functions. Adipose (P)RR mRNA expression was significantly correlated with BMI ( r = 0.526, P = 0.044) and body fat mass ( r = 0.728, P = 0.026, n = 9). GH deficiency was significantly associated with (P)RR mRNA after adjustment for obesity (β = 2.257, 95% CI: 0.367–4.417, P = 0.023). Adipose (P)RR expression may be increased in GH deficiency, suggesting the possible role of adipose (P)RR in fat accumulation in GH deficiency.
Takano et al. (Thu,) conducted a observational in Non-functioning hypothalamic-pituitary masses (n=15). Growth hormone deficiency vs. No growth hormone deficiency was evaluated on Adipose (pro)renin receptor mRNA expression (β 2.257, 95% CI 0.367-4.417, p=0.023). Growth hormone deficiency was significantly associated with higher adipose (pro)renin receptor mRNA expression after adjustment for obesity (β 2.257, 95% CI 0.367-4.417, P=0.023).