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Demonstrates that ageing promotes metastasis in lung cancer, highlighting the impact of cellular stress.
In a recent study published in Nature, Angana A. H. Patel and colleagues revisit the role of physiological ageing in cancer and show that ageing can actively reshape tumour progression. Their work suggests that ageing promotes metastatic dissemination through sustained activation of the integrated stress response (ISR)–activating transcription factor 4 (ATF4) signalling axis, thereby providing a mechanistic link between age-associated cellular stress and metastatic competence. 1
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Lee et al. (2026) studied this question.
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