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July 18, 2026Neuropathology

CD163 Dominance Within Macrophages/Microglia Reflects a Favorable Prognosis in Patients With Glioblastoma

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Authors

MMMayuko MoritsuboKurume UniversityTFTakuya FurutaHokkaido University of ScienceAHAya HashimotoKurume University

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Overview

Randomized trial shows that CD163 dominance improves survival rates in glioblastoma, suggesting new treatment avenues.

Key Points

  • This research investigates the role of CD163 in macrophages/microglia as a prognostic factor for glioblastoma.
  • Analyzed tissues from 34 glioblastoma patients
  • Identified CD163 and IBA-1 dominance in tumor tissues
  • Evaluated overall survival and tumor characteristics based on macrophage phenotype
  • CD163-dominant tumors had an overall survival HR of 0.17 (p=0.011) compared to IBA-1-dominant tumors
  • CD163 dominance correlated with increased CD4-positive cell infiltration (p=0.005)
  • Fewer ameboid TAMs (p=0.021) and non-MVP vessels (p=0.012) were found in CD163-dominant tumors

Cite This Study

Moritsubo et al. (2026) studied this question.

synapsesocial.com/papers/6a5b178d18557b26c2039c23https://doi.org/10.1111/neup.70071
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