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July 18, 2026The Egyptian Journal of Neurosurgery : the official publication of the Egyptian Society of Neurological Surgeons/Egyptian journal of neurosurgeryOpen Access

Brain tumors in infancy and early childhood: a retrospective cohort study from a low- and middle-income country

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Authors

SKShah KhalidSASalaar AhmedZJZanib Javed

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Overview

Retrospective cohort study details brain tumor characteristics in children under three years, highlighting treatment outcomes.

Key Points

  • This study aims to describe brain tumors in children under three years, focusing on clinical presentation, histopathology, and outcomes.
  • Retrospective cohort study at Aga Khan University Hospital, Karachi, including children under three with brain tumors from 2013 to 2024.
  • Survival analyses conducted using Kaplan-Meier curves and Cox proportional hazards regression.
  • Data included demographic details, clinical presentations, tumor characteristics, and treatment outcomes.
  • 50 children under three years were diagnosed with brain tumors over 11.5 years, with a mortality rate of 68%.
  • Ependymomas and medulloblastomas were the most common, with gross total resection in 53.1% of cases.
  • Improved overall survival associated with greater extent of resection and receipt of adjuvant therapy.

Cite This Study

Khalid et al. (2026) studied this question.

synapsesocial.com/papers/6a5b17e818557b26c2039ed9https://doi.org/10.1186/s41984-026-00626-7
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intracranial Tumors of Infants and Children1971 · 224 citations
  2. 2Intracranial Neoplasms during the First Year of Life: Analysis of One Hundred Consecutive Cases1984 · 127 citations