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July 18, 2026Current Opinion in BiotechnologyOpen Access

Systems approaches for optimizing CO2 fixation pathways

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Authors

EHElton P. HudsonSLSara LupacchiniEHElton P. Hudson

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Overview

Survey reveals methods to enhance CO2 fixation pathways in microbial strains, indicating room for improvement in efficiency.

Key Points

  • The aim is to identify and address the discrepancies between designed CO2 fixation pathways and productive microbial strains.
  • Surveyed recent works on CO2 fixation pathway design and implementation.
  • Utilized systems biology tools including kinetic models and proteomics for pathway optimization.
  • Employed in vivo optimization via adaptive laboratory evolution to enhance pathway integration.
  • Identified gaps in pathway performance linked to energy usage and regulatory mechanisms during evolution.
  • Demonstrated that cells adjust their proteome significantly to optimize CO2 fixation pathways.
  • Showed how kinetic modeling and proteomics can inform on host strain adaptations to new pathways.

Cite This Study

Hudson et al. (2026) studied this question.

synapsesocial.com/papers/6a5b183e18557b26c203a2eahttps://doi.org/10.1016/j.copbio.2026.103551
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